Best Builds to Take Down Malignant Heart in Diablo 4

[Garcia]

Several strong Diablo 4 builds are especially good at bossing and single‑target damage, which makes them ideal for taking down content tied to Malignant Hearts. These builds focus on survivability, consistent damage uptime, and synergy with high‑value Hearts.​

Key Barbarian Builds

Whirlwind / Bleed Barbarian excels with Hearts that boost Critical Strike damage, Fury generation, and bleed or damage‑over‑time effects, letting Whirlwind and bleeds shred bosses while staying mobile.​

A Hammer of the Ancients or Upheaval Barbarian benefits from Hearts that reward heavy Fury spending and high crit chance, giving enormous burst windows during vulnerable phases while defensive Hearts supply barriers or damage reduction.​

Top Rogue Builds

Twisting Blades Rogue is one of the highest single‑target damage setups, pairing well with Hearts that turn crits into explosions, supply resource sustain, and reduce incoming burst damage in melee.​

Penetrating Shot Rogue makes excellent use of Hearts that massively increase Critical Strike damage and reward high crit chance, allowing arrows to pierce and delete bosses and any adds in their path.​

Powerful Sorcerer Builds

Firewall Sorcerer scales hard with Hearts that amplify damage over time and elemental cycling, turning stacked Firewalls and crowd control into devastating boss DPS with added defensive bonuses.​

Conjuration or tri‑element Sorcerer can stack Hearts that boost multi‑element casting and critical damage, using Hydras, Ice Blades, and Lightning Spears to maintain constant pressure while staying at range.​

Strong Necromancer and Druid Options

Bone Spirit or Infinimist Necromancer performs extremely well with Hearts that auto‑cast corpse skills and enhance curses or minion damage, allowing near‑constant explosions and strong sustain in boss arenas.youtube+1​

Minion or Pulverize Druid leverages Hearts that massively boost minion or core‑skill damage and provide extra defensive layering, creating a safe, tanky platform for steady boss damage.​

Malignant Heart Priority Tips

Prioritize Wrathful Hearts that give multiplicative damage, explosions, or powerful rotating buffs, as these often provide the biggest jump for boss damage across almost all classes.​

Use Brutal and Vicious Hearts to round out defenses and crit scaling, then tailor your exact selection to your chosen build’s main damage type and resource needs for the best boss‑killing performance.